| 1. Ronde | 04.09.2021 | Hércules CF | - | Recreativo Granada | 1:1 |  |
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| 2. Ronde | 12.09.2021 | CF Intercity | - | Hércules CF | 1:2 | ||||
| 6. Ronde | 10.10.2021 | CA Pulpileño | - | Hércules CF | 0:4 | |
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| 8. Ronde | 24.10.2021 | CD El Ejido 2012 | - | Hércules CF | 0:1 | ||||
| 9. Ronde | 31.10.2021 | Hércules CF | - | CF La Nucía | 0:0 | ||||
| 11. Ronde | 14.11.2021 | CS Puertollano CF | - | Hércules CF | 2:1 | ||||
| 12. Ronde | 21.11.2021 | Hércules CF | - | Real Murcia | 3:0 | ||||
| 13. Ronde | 28.11.2021 | UD Melilla | - | Hércules CF | 1:2 | ||||
| 15. Ronde | 12.12.2021 | Atlético Mancha Real | - | Hércules CF | 1:2 | |
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| 17. Ronde | 09.01.2022 | CD Marchamalo | - | Hércules CF | 0:1 |
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