| 1. Ronde | 05.02.2011 | Defensor Sporting | - | River Plate | 4:1 |  |
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| 2. Ronde | 12.02.2011 | Liverpool | - | Defensor Sporting | 1:2 | ||||
| 3. Ronde | 20.02.2011 | CA Cerro | - | Defensor Sporting | 2:1 | ||||
| 4. Ronde | 27.02.2011 | Montevideo Wanderers | - | Defensor Sporting | 0:1 | ||||
| 5. Ronde | 05.03.2011 | El Tanque Sisley | - | Defensor Sporting | 0:1 | ||||
| 6. Ronde | 13.03.2011 | Bella Vista | - | Defensor Sporting | 1:1 | ||||
| 7. Ronde | 19.03.2011 | Defensor Sporting | - | Miramar Misiones | 2:0 | |
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| 8. Ronde | 02.04.2011 | Defensor Sporting | - | Danubio | 1:1 | |
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| 9. Ronde | 10.04.2011 | Rampla Juniors | - | Defensor Sporting | 0:0 | ||||
| 10. Ronde | 17.04.2011 | Fénix | - | Defensor Sporting | 0:1 | |
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| 11. Ronde | 24.04.2011 | Defensor Sporting | - | Racing | 3:0 | ||||
| 12. Ronde | 07.05.2011 | Central Español | - | Defensor Sporting | 2:0 | ||||
| 13. Ronde | 22.05.2011 | Defensor Sporting | - | Peñarol | 1:1 | ||||
| 14. Ronde | 28.05.2011 | Nacional | - | Defensor Sporting | 3:0 | ||||
| 15. Ronde | 05.06.2011 | Defensor Sporting | - | Tacuarembó | 1:0 | |
Uruguay
