| 1. Ronde | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Ronde | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 6. Ronde | 12.02.2022 | Mazatlán FC [] | - | Club Tijuana [] | 1:3 | ||||
| 9. Ronde | 05.03.2022 | Santos Laguna [] | - | Club Tijuana [] | 2:1 |  |
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| 14. Ronde | 05.04.2022 | Atlético San Luis [] | - | Club Tijuana [] | 0:3 |
Mexico