| 1. Ronde | 08.01.2022 | Gallos Blancos [] | - | CF América [] | 0:4 | ||||
| 2. Ronde | 26.01.2022 | CF América [] | - | Pumas UNAM [] | 1:2 | ||||
| 4. Ronde | 29.01.2022 | CF Pachuca [] | - | CF América [] | 3:0 | ||||
| 9. Ronde | 05.03.2022 | Cruz Azul [] | - | CF América [] | 3:1 | ||||
| 10. Ronde | 12.03.2022 | CF América [] | - | Gallos Blancos [] | 0:1 | ||||
| 11. Ronde | 19.03.2022 | Pumas UNAM [] | - | CF América [] | 1:1 | ||||
| 13. Ronde | 03.04.2022 | Club Necaxa [] | - | CF América [] | 1:2 | ||||
| 14. Ronde | 27.04.2022 | CF América [] | - | Cruz Azul [] | 6:1 | ||||
| 17. Ronde | 30.04.2022 | Puebla FC [] | - | CF América [] | 2:3 |
Mexico