| 1. Ronde | 06.08.2021 | AS Monaco | - | FC Nantes | 1:1 | ||||
| 2. Ronde | 13.08.2021 | FC Lorient | - | AS Monaco | 1:0 | ||||
| 3. Ronde | 21.08.2021 | AS Monaco | - | RC Lens | 0:2 | ||||
| 6. Ronde | 19.09.2021 | OGC Nice | - | AS Monaco | 2:2 |  |
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| 7. Ronde | 22.09.2021 | AS Monaco | - | AS Saint-Étienne | 3:1 | |
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| 8. Ronde | 26.09.2021 | Clermont Foot 63 | - | AS Monaco | 1:3 | ||||
| 12. Ronde | 31.10.2021 | Stade Brestois 29 | - | AS Monaco | 2:0 | ||||
| 16. Ronde | 01.12.2021 | Angers SCO | - | AS Monaco | 1:3 | |
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| 17. Ronde | 05.12.2021 | AS Monaco | - | FC Metz | 4:0 | ||||
| 18. Ronde | 12.12.2021 | Paris Saint-Germain | - | AS Monaco | 2:0 | ||||
| 19. Ronde | 22.12.2021 | AS Monaco | - | Stade Rennais | 2:1 | ||||
| 20. Ronde | 09.01.2022 | FC Nantes | - | AS Monaco | 0:0 | ||||
| 24. Ronde | 13.02.2022 | AS Monaco | - | FC Lorient | 0:0 | ||||
| 25. Ronde | 20.02.2022 | Girondins Bordeaux | - | AS Monaco | 1:1 | |
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| 28. Ronde | 13.03.2022 | RC Strasbourg | - | AS Monaco | 1:0 | ||||
| 34. Ronde | 23.04.2022 | AS Saint-Étienne | - | AS Monaco | 1:4 | |
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| 35. Ronde | 01.05.2022 | AS Monaco | - | Angers SCO | 2:0 |
Frankrijk
Mali 
