| 2. Ronde | 15.01.2022 | Cruz Azul [U20] | - | FC Juárez [U20] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 | ||||
| 5. Ronde | 12.02.2022 | Cruz Azul [U20] | - | Club Necaxa [U20] | 0:1 |  |
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| 6. Ronde | 20.02.2022 | Deportivo Toluca [U20] | - | Cruz Azul [U20] | 1:1 | |
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| 7. Ronde | 27.02.2022 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 |  |
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| 9. Ronde | 05.03.2022 | Cruz Azul [U20] | - | Puebla FC [U20] | 3:0 |  |
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| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | |
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| 11. Ronde | 19.03.2022 | CF Pachuca [U20] | - | Cruz Azul [U20] | 1:0 | ||||
| 12. Ronde | 02.04.2022 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 1:0 |
Mexico