| 1. Ronde | 08.01.2022 | Mazatlán FC [] | - | Atlas Guadalajara [] | 0:4 |  |
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| 2. Ronde | 15.01.2022 | Atlas Guadalajara [] | - | Club Tijuana [] | 1:2 | ||||
| 3. Ronde | 22.01.2022 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 6. Ronde | 12.02.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 4:3 |
Mexico