| 1. Ronde | 09.01.2022 | Santos Laguna [U16] | - | CF Monterrey [U16] | 0:0 |  |
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| 5. Ronde | 04.02.2022 | Atlético San Luis [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 6. Ronde | 12.02.2022 | Santos Laguna [U16] | - | Atlas Guadalajara [U16] | 5:3 |  |
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| 7. Ronde | 18.02.2022 | Club León [U16] | - | Santos Laguna [U16] | 0:0 | ||||
| 8. Ronde | 26.02.2022 | Mazatlán FC [U16] | - | Santos Laguna [U16] | 2:0 | |
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| 9. Ronde | 05.03.2022 | Santos Laguna [U16] | - | Club Tijuana [U16] | 2:0 | ||||
| 10. Ronde | 12.03.2022 | Atlas Guadalajara [U16] | - | Santos Laguna [U16] | 2:3 | |
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| 15. Ronde | 20.04.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 | |
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| 18. Ronde | 07.05.2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico