| 1. Ronde | 05.09.2021 | Real Avilés | - | Marino de Luanco | 2:1 | ||||
| 2. Ronde | 12.09.2021 | UD Llanera | - | Real Avilés | 1:1 | ||||
| 3. Ronde | 19.09.2021 | Real Avilés | - | Gimnástica Segoviana | 1:1 | ||||
| 5. Ronde | 03.10.2021 | Real Avilés | - | Unión Adarve | 2:1 | ||||
| 6. Ronde | 10.10.2021 | CDA Navalcarnero | - | Real Avilés | 0:0 | ||||
| 7. Ronde | 17.10.2021 | CD Cristo Atlético | - | Real Avilés | 1:2 | ||||
| 8. Ronde | 24.10.2021 | Real Avilés | - | Arosa SC | 2:1 | ||||
| 9. Ronde | 30.10.2021 | UP Langreo | - | Real Avilés | 2:1 | ||||
| 10. Ronde | 07.11.2021 | Real Avilés | - | Unión Club Ceares | 3:1 |  |
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| 11. Ronde | 14.11.2021 | Salamanca CF UDS | - | Real Avilés | 0:0 | ||||
| 13. Ronde | 27.11.2021 | SD Compostela | - | Real Avilés | 3:2 | |
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| 15. Ronde | 12.12.2021 | CD Leganés B | - | Real Avilés | 0:1 | ||||
| 17. Ronde | 09.01.2022 | CD Arenteiro | - | Real Avilés | 1:0 |
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