| 3. Ronde | 03.03.2022 | Barnechea | - | San Luis | 3:1 | ||||
| 9. Ronde | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Ronde | 22.04.2022 | Puerto Montt | - | San Luis | 1:1 | ||||
| 12. Ronde | 30.04.2022 | San Luis | - | Deportes Temuco | 1:1 | ||||
| 13. Ronde | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 14. Ronde | 13.05.2022 | San Luis | - | Fernández Vial | 0:0 |  |
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| 15. Ronde | 18.05.2022 | Santa Cruz | - | San Luis | 2:0 |  |
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| 22. Ronde | 01.08.2022 | Santiago Morning | - | San Luis | 1:0 | |
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| 24. Ronde | 16.08.2022 | Deportes Copiapó | - | San Luis | 1:1 | ||||
| 26. Ronde | 31.08.2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 30. Ronde | 04.10.2022 | San Luis | - | Deportes Iquique | 0:0 | ||||
| 31. Ronde | 10.10.2022 | Fernández Vial | - | San Luis | 1:1 | ||||
| 33. Ronde | 24.10.2022 | San Luis | - | Recoleta | 2:1 | ||||
| 34. Ronde | 01.11.2022 | Universidad de Concepción | - | San Luis | 3:1 |
Chili