| 1. Ronde | 05.09.2021 | Real Murcia | - | CD Marchamalo | 3:2 |  |
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| 2. Ronde | 11.09.2021 | Recreativo Granada | - | Real Murcia | 0:0 | |
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| 3. Ronde | 19.09.2021 | Real Murcia | - | CF Intercity | 2:0 | ||||
| 5. Ronde | 03.10.2021 | Real Murcia | - | UD Alzira | 1:0 | ||||
| 6. Ronde | 10.10.2021 | UD Socuéllamos | - | Real Murcia | 0:0 | ||||
| 7. Ronde | 17.10.2021 | Real Murcia | - | CA Pulpileño | 1:1 | ||||
| 8. Ronde | 24.10.2021 | Levante UD B | - | Real Murcia | 1:1 |  |
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| 10. Ronde | 07.11.2021 | CF La Nucía | - | Real Murcia | 1:2 | ||||
| 11. Ronde | 14.11.2021 | Real Murcia | - | CD Eldense | 1:2 | |
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| 12. Ronde | 21.11.2021 | Hércules CF | - | Real Murcia | 3:0 | ||||
| 13. Ronde | 28.11.2021 | CS Puertollano CF | - | Real Murcia | 1:2 | ||||
| 14. Ronde | 05.12.2021 | Real Murcia | - | UD Melilla | 0:0 | ||||
| 15. Ronde | 12.12.2021 | Águilas FC | - | Real Murcia | 1:2 | ||||
| 16. Ronde | 19.12.2021 | Real Murcia | - | Atlético Mancha Real | 1:0 | ||||
| 17. Ronde | 09.01.2022 | CD Toledo | - | Real Murcia | 0:3 | ||||
| 18. Ronde | 23.01.2022 | CD Marchamalo | - | Real Murcia | 1:1 |
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