| 1. Ronde | 08.01.2022 | Pumas UNAM [U16] | - | Cruz Azul [U16] | 1:2 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [U16] | - | CF Pachuca [U16] | 4:2 | ||||
| 3. Ronde | 22.01.2022 | Club Necaxa [U16] | - | Cruz Azul [U16] | 2:1 | ||||
| 8. Ronde | 26.02.2022 | Cruz Azul [U16] | - | Puebla FC [U16] | 1:2 | ||||
| 10. Ronde | 12.03.2022 | CF Pachuca [U16] | - | Cruz Azul [U16] | 2:2 | ||||
| 15. Ronde | 23.03.2022 | Cruz Azul [U16] | - | Pumas UNAM [U16] | 0:2 | ||||
| 12. Ronde | 26.03.2022 | Cruz Azul [U16] | - | FC Juárez [U16] | 7:3 |  |
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| 13. Ronde | 02.04.2022 | Cruz Azul [U16] | - | Deportivo Toluca [U16] | 0:1 | ||||
| 18. Ronde | 07.05.2022 | Cruz Azul [U16] | - | Club Necaxa [U16] | 2:4 |
Mexico