| 1. Ronde | 27.08.2021 | Cultural Leonesa | - | Rayo Majadahonda | 0:2 | ||||
| 2. Ronde | 05.09.2021 | Unionistas CF | - | Cultural Leonesa | 2:2 | ||||
| 3. Ronde | 12.09.2021 | Cultural Leonesa | - | Athletic Club B | 2:1 |  |
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| 4. Ronde | 19.09.2021 | Inter de Madrid | - | Cultural Leonesa | 3:2 | ||||
| 6. Ronde | 02.10.2021 | CD Badajoz | - | Cultural Leonesa | 3:3 | ||||
| 7. Ronde | 09.10.2021 | Cultural Leonesa | - | CF Talavera | 1:2 | ||||
| 10. Ronde | 30.10.2021 | CD Tudelano | - | Cultural Leonesa | 1:1 | ||||
| 11. Ronde | 07.11.2021 | Cultural Leonesa | - | Racing Santander | 3:0 | |
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| 12. Ronde | 12.11.2021 | SD Logroñés | - | Cultural Leonesa | 1:1 | |
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| 16. Ronde | 11.12.2021 | Zamora CF | - | Cultural Leonesa | 2:2 | ||||
| 17. Ronde | 19.12.2021 | Cultural Leonesa | - | Deportivo La Coruña | 2:3 | ||||
| 18. Ronde | 08.01.2022 | UD Logroñés | - | Cultural Leonesa | 0:0 |
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