| 1. Ronde | 05.09.2021 | CS Puertollano CF | - | CA Pulpileño | 2:0 | ||||
| 10. Ronde | 07.11.2021 | CF Intercity | - | CS Puertollano CF | 4:0 | ||||
| 12. Ronde | 21.11.2021 | Mar Menor CF | - | CS Puertollano CF | 1:0 |  |
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| 15. Ronde | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 |  |
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| 17. Ronde | 09.01.2022 | Águilas FC | - | CS Puertollano CF | 1:0 | ||||
| 19. Ronde | 30.01.2022 | CS Puertollano CF | - | Atlético Mancha Real | 1:2 | ||||
| 23. Ronde | 27.02.2022 | CS Puertollano CF | - | CD Marchamalo | 1:2 | |
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| 24. Ronde | 06.03.2022 | CF La Nucía | - | CS Puertollano CF | 3:2 | ||||
| 25. Ronde | 13.03.2022 | CS Puertollano CF | - | Recreativo Granada | 3:0 | ||||
| 26. Ronde | 20.03.2022 | CD Eldense | - | CS Puertollano CF | 3:2 | ||||
| 27. Ronde | 27.03.2022 | CS Puertollano CF | - | CF Intercity | 0:1 | |
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| 28. Ronde | 03.04.2022 | Hércules CF | - | CS Puertollano CF | 2:1 | |
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| 29. Ronde | 10.04.2022 | CS Puertollano CF | - | Mar Menor CF | 4:0 | |
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| 30. Ronde | 17.04.2022 | Real Murcia | - | CS Puertollano CF | 3:1 | ||||
| 31. Ronde | 24.04.2022 | CS Puertollano CF | - | UD Alzira | 1:3 | ||||
| 32. Ronde | 01.05.2022 | UD Melilla | - | CS Puertollano CF | 2:1 | |
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| 34. Ronde | 15.05.2022 | CS Puertollano CF | - | Águilas FC | 1:2 | |
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