| 17. Ronde | 09.01.2022 | CD Marchamalo | - | Hércules CF | 0:1 |  |
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| 19. Ronde | 30.01.2022 | UD Melilla | - | CD Marchamalo | 4:1 | ||||
| 23. Ronde | 27.02.2022 | CS Puertollano CF | - | CD Marchamalo | 1:2 | ||||
| 25. Ronde | 13.03.2022 | CD Marchamalo | - | CF Intercity | 2:2 | ||||
| 27. Ronde | 27.03.2022 | CD Marchamalo | - | UD Alzira | 4:3 | |
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| 28. Ronde | 03.04.2022 | UD Socuéllamos | - | CD Marchamalo | 1:0 | ||||
| 31. Ronde | 24.04.2022 | CD Marchamalo | - | CD El Ejido 2012 | 4:2 |
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