| 6. Ronde | 14.02.2021 | Santos Laguna [U17] | - | CF Monterrey [U17] | 2:1 |  |
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| 9. Ronde | 04.03.2021 | Pumas UNAM [U17] | - | Santos Laguna [U17] | 2:1 | ||||
| 11. Ronde | 13.03.2021 | Club Tijuana [U17] | - | Santos Laguna [U17] | 3:1 | |
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| 12. Ronde | 21.03.2021 | Santos Laguna [U17] | - | Club León [U17] | 1:1 | ||||
| 13. Ronde | 04.04.2021 | Deportivo Guadalajara [U17] | - | Santos Laguna [U17] | 2:0 | ||||
| 16. Ronde | 26.04.2021 | CF Pachuca [U17] | - | Santos Laguna [U17] | 4:2 |
Mexico