| 1. Ronde | 28.08.2021 | SD Logroñés | - | Real Valladolid B | 1:1 | ||||
| 3. Ronde | 11.09.2021 | Racing Ferrol | - | Real Valladolid B | 2:1 | ||||
| 4. Ronde | 18.09.2021 | Real Valladolid B | - | UD SS Reyes | 2:2 | ||||
| 5. Ronde | 25.09.2021 | Cultural Leonesa | - | Real Valladolid B | 4:2 | ||||
| 12. Ronde | 14.11.2021 | Celta de Vigo B | - | Real Valladolid B | 3:0 | ||||
| 15. Ronde | 05.12.2021 | Real Valladolid B | - | Racing Santander | 3:0 | ||||
| 16. Ronde | 12.12.2021 | Deportivo La Coruña | - | Real Valladolid B | 3:0 | ||||
| 18. Ronde | 08.01.2022 | CD Badajoz | - | Real Valladolid B | 1:2 | ||||
| 19. Ronde | 22.01.2022 | Real Valladolid B | - | CD Tudelano | 0:2 | ||||
| 22. Ronde | 05.02.2022 | Real Valladolid B | - | Celta de Vigo B | 1:3 | ||||
| 24. Ronde | 20.02.2022 | Real Valladolid B | - | Racing Ferrol | 1:2 | ||||
| 25. Ronde | 25.02.2022 | Athletic Club B | - | Real Valladolid B | 3:0 | ||||
| 21. Ronde | 02.03.2022 | Real Unión | - | Real Valladolid B | 2:1 | ||||
| 26. Ronde | 06.03.2022 | Real Valladolid B | - | UD Logroñés | 0:2 | ||||
| 27. Ronde | 06.04.2022 | Real Valladolid B | - | CF Talavera | 2:1 |  |
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| 38. Ronde | 28.05.2022 | Zamora CF | - | Real Valladolid B | 2:0 |
Ghana