| 1. Ronde | 09.01.2022 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 8. Ronde | 01.03.2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 10. Ronde | 11.03.2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 | ||||
| 11. Ronde | 20.03.2022 | Mazatlán FC [U20] | - | Club León [U20] | 1:0 | ||||
| 9. Ronde | 27.03.2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 |  |
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| 13. Ronde | 08.04.2022 | Mazatlán FC [U20] | - | Cruz Azul [U20] | 0:0 | ||||
| 14. Ronde | 14.04.2022 | Atlas Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 |
Mexico