| 26. Ronde | 06.03.2022 | Real Valladolid B | - | UD Logroñés | 0:2 |  |
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| 28. Ronde | 20.03.2022 | Unionistas CF | - | Real Valladolid B | 0:0 | ||||
| 27. Ronde | 06.04.2022 | Real Valladolid B | - | CF Talavera | 2:1 | ||||
| 31. Ronde | 10.04.2022 | Real Valladolid B | - | SD Logroñés | 2:0 | ||||
| 33. Ronde | 24.04.2022 | Real Valladolid B | - | Cultural Leonesa | 3:3 | ||||
| 35. Ronde | 07.05.2022 | Real Valladolid B | - | CD Badajoz | 1:0 | |
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| 36. Ronde | 15.05.2022 | Racing Santander | - | Real Valladolid B | 1:0 | ||||
| 37. Ronde | 21.05.2022 | Real Valladolid B | - | Deportivo La Coruña | 0:4 |
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