| 30. Ronde | 05.03.2022 | CD Tenerife | - | Real Valladolid | 1:4 | ||||
| 32. Ronde | 19.03.2022 | Real Valladolid | - | UD Las Palmas | 0:1 | ||||
| 33. Ronde | 27.03.2022 | AD Alcorcón | - | Real Valladolid | 1:2 | ||||
| 34. Ronde | 02.04.2022 | Real Valladolid | - | CD Lugo | 4:1 | ||||
| 35. Ronde | 09.04.2022 | Málaga CF | - | Real Valladolid | 2:2 | ||||
| 36. Ronde | 16.04.2022 | Real Valladolid | - | UD Almería | 2:2 | ||||
| 37. Ronde | 24.04.2022 | CD Mirandés | - | Real Valladolid | 0:1 | ||||
| 38. Ronde | 02.05.2022 | Real Valladolid | - | Real Sociedad B | 1:2 |  |
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| 39. Ronde | 08.05.2022 | SD Eibar | - | Real Valladolid | 0:2 | ||||
| 40. Ronde | 14.05.2022 | Real Valladolid | - | SD Ponferradina | 2:0 | |
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| 41. Ronde | 21.05.2022 | UD Ibiza | - | Real Valladolid | 1:2 | ||||
| 42. Ronde | 29.05.2022 | Real Valladolid | - | SD Huesca | 3:0 |
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