| 2. Ronde | 25.09.2021 | CF Monterrey [] | - | Mazatlán FC [] | 4:1 | ||||
| 3. Ronde | 02.10.2021 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 4. Ronde | 09.10.2021 | CF Monterrey [] | - | Atlético San Luis [] | 4:0 | ||||
| 5. Ronde | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | ||||
| 9. Ronde | 13.11.2021 | CF Monterrey [] | - | Club León [] | 2:2 | ||||
| 10. Ronde | 20.11.2021 | Club Necaxa [] | - | CF Monterrey [] | 1:1 |  |
Mexico