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| 20.11.2021 | Atlético San Luis | - | Atlas Guadalajara | niet gespeeld | ||
| 16:00 | CF Pachuca | - | Gallos Blancos | 2:1 (0:1) | ||
| 16:30 | Club Necaxa | - | CF Monterrey | 1:1 (0:0) | ||
| 17:00 | Puebla FC | - | Pumas UNAM | 2:4 (0:3) | ||
| 18:15 | UANL Tigres | - | Deportivo Guadalajara | 0:1 (0:1) | ||
| 18:30 | Club León | - | Santos Laguna | 4:2 (3:1) | ||
| 19:30 | FC Juárez | - | CF América | 1:2 (1:0) | ||
| 21:45 | Club Tijuana | - | Cruz Azul | 1:2 (0:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 9 | 7 | 1 | 1 | 31:16 | 15 | 22 |
| 2 |
|
CF Pachuca | 9 | 6 | 1 | 2 | 35:16 | 19 | 19 |
| 3 |
|
Pumas UNAM | 9 | 4 | 3 | 2 | 21:15 | 6 | 15 |
| 4 |
|
Deportivo Toluca | 9 | 4 | 1 | 4 | 17:16 | 1 | 13 |
| 5 |
|
FC Juárez | 9 | 4 | 1 | 4 | 12:22 | -10 | 13 |
| 6 |
|
Club Tijuana | 9 | 3 | 1 | 5 | 16:18 | -2 | 10 |
| 7 |
|
Cruz Azul | 9 | 2 | 3 | 4 | 17:24 | -7 | 9 |
| 8 |
|
Puebla FC | 9 | 2 | 1 | 6 | 9:25 | -16 | 7 |
| 9 |
|
Gallos Blancos | 8 | 1 | 2 | 5 | 6:12 | -6 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 9 | 8 | 0 | 1 | 23:7 | 16 | 24 |
| 2 |
|
Club Necaxa | 9 | 5 | 2 | 2 | 21:11 | 10 | 17 |
| 3 |
|
Club León | 9 | 4 | 3 | 2 | 19:17 | 2 | 15 |
| 4 |
|
Atlas Guadalajara | 8 | 5 | 0 | 3 | 14:13 | 1 | 15 |
| 5 |
|
UANL Tigres | 9 | 4 | 2 | 3 | 19:12 | 7 | 14 |
| 6 |
|
Santos Laguna | 9 | 3 | 1 | 5 | 12:17 | -5 | 10 |
| 7 |
|
CF Monterrey | 8 | 2 | 2 | 4 | 15:15 | 0 | 8 |
| 8 |
|
Mazatlán FC | 9 | 0 | 3 | 6 | 10:23 | -13 | 3 |
| 9 |
|
Atlético San Luis | 8 | 0 | 3 | 5 | 7:25 | -18 | 3 |
