| 1. Ronde | 05.09.2021 | UD Melilla | - | CD Toledo | 1:0 | ||||
| 2. Ronde | 12.09.2021 | CD Toledo | - | Águilas FC | 0:1 | ||||
| 3. Ronde | 19.09.2021 | Atlético Mancha Real | - | CD Toledo | 2:0 |  |
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| 5. Ronde | 03.10.2021 | CD Toledo | - | CD Marchamalo | 3:2 | |
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| 6. Ronde | 10.10.2021 | Recreativo Granada | - | CD Toledo | 1:1 | ||||
| 7. Ronde | 17.10.2021 | CD Toledo | - | CF Intercity | 0:1 | ||||
| 8. Ronde | 24.10.2021 | Mar Menor CF | - | CD Toledo | 2:0 | ||||
| 9. Ronde | 31.10.2021 | CD Toledo | - | UD Alzira | 1:2 | ||||
| 10. Ronde | 07.11.2021 | UD Socuéllamos | - | CD Toledo | 1:1 | ||||
| 11. Ronde | 14.11.2021 | CD Toledo | - | CA Pulpileño | 0:1 | ||||
| 12. Ronde | 21.11.2021 | Levante UD B | - | CD Toledo | 0:2 | ||||
| 13. Ronde | 28.11.2021 | CD Toledo | - | CD El Ejido 2012 | 0:1 | ||||
| 14. Ronde | 05.12.2021 | CF La Nucía | - | CD Toledo | 2:0 | ||||
| 15. Ronde | 12.12.2021 | CD Toledo | - | CD Eldense | 1:1 | ||||
| 16. Ronde | 19.12.2021 | Hércules CF | - | CD Toledo | 1:0 |
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