| 4. Ronde | 26.09.2021 | CD Toledo | - | CS Puertollano CF | 1:4 | ||||
| 6. Ronde | 10.10.2021 | CD Marchamalo | - | CS Puertollano CF | 0:0 | ||||
| 8. Ronde | 24.10.2021 | Recreativo Granada | - | CS Puertollano CF | 2:1 | ||||
| 9. Ronde | 31.10.2021 | CS Puertollano CF | - | CD Eldense | 0:1 | ||||
| 15. Ronde | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 | ||||
| 17. Ronde | 09.01.2022 | Águilas FC | - | CS Puertollano CF | 1:0 |  |
|||
| 20. Ronde | 05.02.2022 | Levante UD B | - | CS Puertollano CF | 0:0 | ||||
| 25. Ronde | 13.03.2022 | CS Puertollano CF | - | Recreativo Granada | 3:0 | |
|||
| 26. Ronde | 20.03.2022 | CD Eldense | - | CS Puertollano CF | 3:2 |
Spanje