| 1. Ronde | 05.09.2021 | Cerdanyola FC | - | CD Brea | 2:1 | ||||
| 2. Ronde | 12.09.2021 | CD Brea | - | Terrassa FC | 1:1 | ||||
| 3. Ronde | 19.09.2021 | Peña Deportiva | - | CD Brea | 3:0 | ||||
| 4. Ronde | 26.09.2021 | CD Brea | - | SD Ejea | 3:2 | ||||
| 5. Ronde | 03.10.2021 | SD Huesca B | - | CD Brea | 1:1 | ||||
| 6. Ronde | 10.10.2021 | CD Brea | - | SD Formentera | 1:3 | ||||
| 7. Ronde | 17.10.2021 | CD Brea | - | CD Numancia | 1:0 |  |
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| 8. Ronde | 24.10.2021 | AE Prat | - | CD Brea | 1:1 |  |
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| 9. Ronde | 31.10.2021 | CD Brea | - | CF Badalona | 2:1 | |
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| 10. Ronde | 07.11.2021 | CE Europa | - | CD Brea | 1:0 |
Spanje