| 3. Ronde | 28.02.2022 | Deportes Iquique | - | Deportes Temuco | 1:0 |  |
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| 5. Ronde | 16.03.2022 | Deportes Iquique | - | CD Magallanes | 1:1 |  |
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| 6. Ronde | 22.03.2022 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 7. Ronde | 03.04.2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
| 8. Ronde | 09.04.2022 | Fernández Vial | - | Deportes Iquique | 0:0 | ||||
| 9. Ronde | 17.04.2022 | Deportes Iquique | - | Cobreloa | 2:0 | ||||
| 10. Ronde | 20.04.2022 | Deportes Copiapó | - | Deportes Iquique | 1:0 | |
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| 12. Ronde | 30.04.2022 | Universidad de Concepción | - | Deportes Iquique | 2:2 | ||||
| 13. Ronde | 07.05.2022 | Deportes Iquique | - | San Luis | 1:1 | ||||
| 15. Ronde | 15.05.2022 | Deportes Iquique | - | Recoleta | 2:1 | ||||
| 16. Ronde | 21.05.2022 | Unión San Felipe | - | Deportes Iquique | 2:0 | ||||
| 17. Ronde | 29.05.2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 1. Ronde | 05.06.2022 | Santiago Wanderers | - | Deportes Iquique | 2:0 | ||||
| 18. Ronde | 02.07.2022 | Deportes Iquique | - | Santiago Wanderers | 2:1 |  |
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| 26. Ronde | 31.08.2022 | Cobreloa | - | Deportes Iquique | 2:1 | ||||
| 28. Ronde | 12.09.2022 | Rangers | - | Deportes Iquique | 0:2 |
Chili