| 4. Ronde | 09.10.2021 | Pumas UNAM [] | - | CF Pachuca [] | 1:1 | ||||
| 5. Ronde | 16.10.2021 | CF Pachuca [] | - | FC Juárez [] | 7:0 | ||||
| 6. Ronde | 23.10.2021 | Club Tijuana [] | - | CF Pachuca [] | 4:2 |  |
|||
| 9. Ronde | 13.11.2021 | Deportivo Toluca [] | - | CF Pachuca [] | 4:3 | ||||
| 10. Ronde | 20.11.2021 | CF Pachuca [] | - | Gallos Blancos [] | 2:1 |
Mexico