| 1. Ronde | 06.01.2022 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 0:2 | ||||
| 4. Ronde | 05.02.2022 | CF América [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 7. Ronde | 26.02.2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 11. Ronde | 17.03.2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 14. Ronde | 15.04.2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 |
Mexico