| 1. Ronde | 04.02.2018 | Progreso | - | Danubio | 1:1 | ||||
| 2. Ronde | 11.02.2018 | Danubio | - | Defensor Sporting | 2:1 | ||||
| 3. Ronde | 18.02.2018 | Racing | - | Danubio | 1:2 |  |
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| 4. Ronde | 25.02.2018 | Danubio | - | River Plate | 1:0 | |
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| 5. Ronde | 03.03.2018 | Montevideo Wanderers | - | Danubio | 0:1 | ||||
| 6. Ronde | 10.03.2018 | Danubio | - | Liverpool | 0:3 | ||||
| 10. Ronde | 01.04.2018 | Danubio | - | Atenas | 5:0 | ||||
| 11. Ronde | 07.04.2018 | CA Cerro | - | Danubio | 3:2 | ||||
| 12. Ronde | 15.04.2018 | Torque | - | Danubio | 0:3 | ||||
| 13. Ronde | 21.04.2018 | Danubio | - | Rampla Juniors | 3:1 | ||||
| 14. Ronde | 28.04.2018 | Fénix | - | Danubio | 0:1 | |
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| 15. Ronde | 05.05.2018 | Danubio | - | Nacional | 1:2 |
Uruguay