| 1. Ronde | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 2. Ronde | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 3. Ronde | 31.01.2021 | Danubio | - | Peñarol | 0:1 |  |
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| 4. Ronde | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Ronde | 07.02.2021 | Danubio | - | Montevideo City Torque | 0:4 | ||||
| 7. Ronde | 15.02.2021 | Danubio | - | Progreso | 0:1 | |
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| 8. Ronde | 18.02.2021 | Fénix | - | Danubio | 1:1 | ||||
| 9. Ronde | 22.02.2021 | Danubio | - | CA Cerro | 2:1 | ||||
| 10. Ronde | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 11. Ronde | 07.03.2021 | Danubio | - | Liverpool | 0:1 | ||||
| 12. Ronde | 13.03.2021 | Danubio | - | Nacional | 2:1 | ||||
| 13. Ronde | 19.03.2021 | Boston River | - | Danubio | 1:5 |  |
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| 14. Ronde | 23.03.2021 | Danubio | - | Deportivo Maldonado | 2:2 | |
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| 15. Ronde | 29.03.2021 | Rentistas | - | Danubio | 1:0 |
Uruguay