| 1. Ronde | 31.07.2022 | Deportivo Maldonado | - | Nacional | 2:1 |  |
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| 2. Ronde | 06.08.2022 | Nacional | - | Rentistas | 3:0 |  |
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| 3. Ronde | 14.08.2022 | Liverpool | - | Nacional | 0:1 | |
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| 5. Ronde | 27.08.2022 | Montevideo City Torque | - | Nacional | 0:3 | |
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| 4. Ronde | 04.09.2022 | Nacional | - | Peñarol | 3:1 | ||||
| 7. Ronde | 10.09.2022 | Plaza Colonia | - | Nacional | 1:3 | ||||
| 8. Ronde | 15.09.2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Ronde | 17.09.2022 | River Plate | - | Nacional | 1:1 | ||||
| 10. Ronde | 25.09.2022 | Nacional | - | Cerro Largo | 1:1 | ||||
| 11. Ronde | 01.10.2022 | Fénix | - | Nacional | 1:1 | ||||
| 12. Ronde | 09.10.2022 | Nacional | - | Defensor Sporting | 1:1 | ||||
| 13. Ronde | 14.10.2022 | Albion | - | Nacional | 0:1 | ||||
| 14. Ronde | 18.10.2022 | Cerrito | - | Nacional | 1:2 | ||||
| 15. Ronde | 24.10.2022 | Nacional | - | Danubio | 2:0 |
Uruguay