| 1. Ronde | 25.06.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Ronde | 02.07.2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 |  |
|||
| 4. Ronde | 16.07.2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 | ||||
| 5. Ronde | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | ||||
| 7. Ronde | 06.08.2022 | Atlas Guadalajara [] | - | Santos Laguna [] | 2:2 | ||||
| 8. Ronde | 13.08.2022 | Santos Laguna [] | - | UANL Tigres [] | 2:2 | ||||
| 10. Ronde | 28.08.2022 | Deportivo Guadalajara [] | - | Santos Laguna [] | 1:1 | ||||
| 11. Ronde | 03.09.2022 | Santos Laguna [] | - | Club León [] | 2:0 | ||||
| 12. Ronde | 10.09.2022 | UANL Tigres [] | - | Santos Laguna [] | 0:2 | ||||
| 13. Ronde | 17.09.2022 | Santos Laguna [] | - | Atlas Guadalajara [] | 2:0 |
Mexico