| 2. Ronde | 25.09.2021 | CF Monterrey [] | - | Mazatlán FC [] | 4:1 | ||||
| 3. Ronde | 02.10.2021 | Atlas Guadalajara [] | - | CF Monterrey [] | 2:1 | ||||
| 4. Ronde | 09.10.2021 | CF Monterrey [] | - | Atlético San Luis [] | 4:0 | ||||
| 5. Ronde | 16.10.2021 | Santos Laguna [] | - | CF Monterrey [] | 4:1 | ||||
| 6. Ronde | 23.10.2021 | UANL Tigres [] | - | CF Monterrey [] | 2:1 | ||||
| 7. Ronde | 30.10.2021 | CF Monterrey [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 9. Ronde | 13.11.2021 | CF Monterrey [] | - | Club León [] | 2:2 |
Mexico