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| 30.10.2021 | 17:00 | Mazatlán FC | - | Atlas Guadalajara | 1:2 (0:1) | |
| 18:30 | Club León | - | Atlético San Luis | 2:0 (1:0) | ||
| 18:30 | CF Monterrey | - | Deportivo Guadalajara | 1:3 (0:1) | ||
| 18:30 | Santos Laguna | - | Club Necaxa | 0:2 (0:0) | ||
| 19:00 | Pumas UNAM | - | Cruz Azul | 2:2 (1:1) | ||
| 19:45 | CF América | - | Deportivo Toluca | 2:1 (2:0) | ||
| 21:45 | Club Tijuana | - | Gallos Blancos | 3:0 (0:0) | ||
| 23:00 | Puebla FC | - | FC Juárez | 2:1 (1:0) |
| 1 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF América | 6 | 5 | 1 | 0 | 20:9 | 11 | 16 |
| 2 |
|
CF Pachuca | 6 | 4 | 1 | 1 | 25:8 | 17 | 13 |
| 3 |
|
Pumas UNAM | 6 | 2 | 3 | 1 | 14:9 | 5 | 9 |
| 4 |
|
Club Tijuana | 6 | 3 | 0 | 3 | 13:13 | 0 | 9 |
| 5 |
|
FC Juárez | 6 | 3 | 0 | 3 | 9:19 | -10 | 9 |
| 6 |
|
Deportivo Toluca | 7 | 2 | 1 | 4 | 10:12 | -2 | 7 |
| 7 |
|
Puebla FC | 6 | 2 | 0 | 4 | 4:13 | -9 | 6 |
| 8 |
|
Gallos Blancos | 6 | 1 | 2 | 3 | 5:9 | -4 | 5 |
| 9 |
|
Cruz Azul | 7 | 1 | 2 | 4 | 13:21 | -8 | 5 |
| 2 | |||||||||
| # | Team | GS. | W. | G. | V. | Dp. | Ds. | P. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
Deportivo Guadalajara | 6 | 5 | 0 | 1 | 17:7 | 10 | 15 |
| 2 |
|
Club Necaxa | 6 | 4 | 0 | 2 | 14:6 | 8 | 12 |
| 3 |
|
Atlas Guadalajara | 6 | 4 | 0 | 2 | 11:8 | 3 | 12 |
| 4 |
|
UANL Tigres | 6 | 3 | 2 | 1 | 14:7 | 7 | 11 |
| 5 |
|
Santos Laguna | 6 | 3 | 1 | 2 | 9:8 | 1 | 10 |
| 6 |
|
Club León | 6 | 3 | 1 | 2 | 10:10 | 0 | 10 |
| 7 |
|
CF Monterrey | 6 | 2 | 0 | 4 | 12:12 | 0 | 6 |
| 8 |
|
Mazatlán FC | 7 | 0 | 2 | 5 | 7:18 | -11 | 2 |
| 9 |
|
Atlético San Luis | 7 | 0 | 2 | 5 | 5:23 | -18 | 2 |
