| 1. Ronde | 08.01.2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
| 2. Ronde | 15.01.2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
| 3. Ronde | 22.01.2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
| 5. Ronde | 05.02.2022 | CF Monterrey [] | - | Club León [] | 1:0 | ||||
| 8. Ronde | 26.02.2022 | Atlas Guadalajara [] | - | Club León [] | 4:1 | ||||
| 9. Ronde | 05.03.2022 | Club León [] | - | Mazatlán FC [] | 1:1 |  |
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| 16. Ronde | 23.04.2022 | Club León [] | - | Club Tijuana [] | 2:1 | ||||
| 15. Ronde | 03.05.2022 | Atlético San Luis [] | - | Club León [] | 0:3 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [] | - | Club León [] | 2:3 |
Mexico