| 11. Ronde | 19.03.2022 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:1 | ||||
| 12. Ronde | 26.03.2022 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 3:1 | ||||
| 13. Ronde | 02.04.2022 | CF Monterrey [U16] | - | Santos Laguna [U16] | 2:1 | ||||
| 15. Ronde | 20.04.2022 | Club Tijuana [U16] | - | Santos Laguna [U16] | 0:1 | ||||
| 16. Ronde | 23.04.2022 | Santos Laguna [U16] | - | UANL Tigres [U16] | 5:0 | ||||
| 17. Ronde | 30.04.2022 | Deportivo Guadalajara [U16] | - | Santos Laguna [U16] | 3:0 | ||||
| 18. Ronde | 07.05.2022 | Santos Laguna [U16] | - | Club León [U16] | 2:1 |
Mexico