| 1. Ronde | 06.01.2022 | Atlético San Luis [U20] | - | CF Pachuca [U20] | 0:2 | ||||
| 2. Ronde | 15.01.2022 | Atlas Guadalajara [U20] | - | Atlético San Luis [U20] | 1:3 |  |
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| 3. Ronde | 20.01.2022 | Atlético San Luis [U20] | - | FC Juárez [U20] | 7:1 | |
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| 4. Ronde | 05.02.2022 | CF América [U20] | - | Atlético San Luis [U20] | 0:1 | ||||
| 5. Ronde | 12.02.2022 | Atlético San Luis [U20] | - | Deportivo Toluca [U20] | 4:1 | |
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| 6. Ronde | 19.02.2022 | UANL Tigres [U20] | - | Atlético San Luis [U20] | 1:1 | ||||
| 7. Ronde | 26.02.2022 | CF Monterrey [U20] | - | Atlético San Luis [U20] | 1:3 | ||||
| 8. Ronde | 02.03.2022 | Atlético San Luis [U20] | - | Deportivo Guadalajara [U20] | 2:3 | |
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| 10. Ronde | 13.03.2022 | Atlético San Luis [U20] | - | Puebla FC [U20] | 3:1 | ||||
| 11. Ronde | 17.03.2022 | Gallos Blancos [U20] | - | Atlético San Luis [U20] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 9. Ronde | 06.04.2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 13. Ronde | 09.04.2022 | Atlético San Luis [U20] | - | Club León [U20] | 1:1 | ||||
| 14. Ronde | 15.04.2022 | Club Necaxa [U20] | - | Atlético San Luis [U20] | 3:0 |
Mexico