| 10. Ronde | 22.11.2020 | Granada CF | - | Real Valladolid | 1:3 |  |
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| 11. Ronde | 27.11.2020 | Real Valladolid | - | Levante UD | 1:1 | ||||
| 12. Ronde | 05.12.2020 | Atlético Madrid | - | Real Valladolid | 2:0 | ||||
| 13. Ronde | 11.12.2020 | Real Valladolid | - | CA Osasuna | 3:2 | ||||
| 14. Ronde | 19.12.2020 | Sevilla FC | - | Real Valladolid | 1:1 | ||||
| 15. Ronde | 22.12.2020 | Real Valladolid | - | FC Barcelona | 0:3 | ||||
| 16. Ronde | 29.12.2020 | Cádiz CF | - | Real Valladolid | 0:0 | ||||
| 17. Ronde | 02.01.2021 | Getafe CF | - | Real Valladolid | 0:1 | ||||
| 18. Ronde | 10.01.2021 | Real Valladolid | - | Valencia CF | 0:1 | ||||
| 23. Ronde | 13.02.2021 | SD Eibar | - | Real Valladolid | 1:1 | ||||
| 24. Ronde | 20.02.2021 | Real Valladolid | - | Real Madrid | 0:1 | ||||
| 26. Ronde | 06.03.2021 | Real Valladolid | - | Getafe CF | 2:1 | ||||
| 31. Ronde | 21.04.2021 | Elche CF | - | Real Valladolid | 1:1 | ||||
| 34. Ronde | 02.05.2021 | Real Valladolid | - | Real Betis | 1:1 | ||||
| 35. Ronde | 09.05.2021 | Valencia CF | - | Real Valladolid | 3:0 | ||||
| 37. Ronde | 16.05.2021 | Real Sociedad | - | Real Valladolid | 4:1 | ||||
| 38. Ronde | 22.05.2021 | Real Valladolid | - | Atlético Madrid | 1:2 |
Portugal