| 1. Ronde | 08.01.2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 | ||||
| 2. Ronde | 15.01.2022 | Cruz Azul [U20] | - | FC Juárez [U20] | 0:0 | ||||
| 3. Ronde | 22.01.2022 | CF Monterrey [U20] | - | Cruz Azul [U20] | 2:2 | ||||
| 4. Ronde | 07.02.2022 | Club León [U20] | - | Cruz Azul [U20] | 2:1 |  |
|||
| 6. Ronde | 20.02.2022 | Deportivo Toluca [U20] | - | Cruz Azul [U20] | 1:1 | ||||
| 7. Ronde | 27.02.2022 | Cruz Azul [U20] | - | Santos Laguna [U20] | 2:1 | ||||
| 8. Ronde | 02.03.2022 | UANL Tigres [U20] | - | Cruz Azul [U20] | 1:1 | |
|||
| 9. Ronde | 05.03.2022 | Cruz Azul [U20] | - | Puebla FC [U20] | 3:0 | |
|||
| 10. Ronde | 12.03.2022 | Cruz Azul [U20] | - | Pumas UNAM [U20] | 1:0 Toeg. | ||||
| 12. Ronde | 02.04.2022 | Cruz Azul [U20] | - | Atlas Guadalajara [U20] | 1:0 | |
|||
| 15. Ronde | 21.04.2022 | Gallos Blancos [U20] | - | Cruz Azul [U20] | 1:3 | ||||
| 16. Ronde | 24.04.2022 | Cruz Azul [U20] | - | Atlético San Luis [U20] | 2:2 | |
Mexico