| 1. Ronde | 05.09.2021 | CD Eldense | - | CF Intercity | 0:0 | ||||
| 10. Ronde | 07.11.2021 | CD Eldense | - | Hércules CF | 2:2 | ||||
| 11. Ronde | 14.11.2021 | Real Murcia | - | CD Eldense | 1:2 |  |
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| 12. Ronde | 21.11.2021 | CD Eldense | - | UD Melilla | 2:1 | ||||
| 15. Ronde | 12.12.2021 | CD Toledo | - | CD Eldense | 1:1 | ||||
| 16. Ronde | 18.12.2021 | CD Eldense | - | CD Marchamalo | 4:0 | |
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| 17. Ronde | 09.01.2022 | Recreativo Granada | - | CD Eldense | 1:1 | ||||
| 19. Ronde | 30.01.2022 | CD Eldense | - | Mar Menor CF | 1:0 | ||||
| 21. Ronde | 13.02.2022 | CD Eldense | - | UD Socuéllamos | 0:2 | ||||
| 23. Ronde | 27.02.2022 | CD Eldense | - | Levante UD B | 1:3 | ||||
| 24. Ronde | 06.03.2022 | CD El Ejido 2012 | - | CD Eldense | 1:1 | ||||
| 22. Ronde | 09.03.2022 | CA Pulpileño | - | CD Eldense | 1:3 |  |
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| 28. Ronde | 03.04.2022 | CD Eldense | - | Real Murcia | 1:3 | ||||
| 29. Ronde | 10.04.2022 | UD Melilla | - | CD Eldense | 3:2 | ||||
| 30. Ronde | 17.04.2022 | CD Eldense | - | Águilas FC | 0:1 | ||||
| 33. Ronde | 08.05.2022 | CD Marchamalo | - | CD Eldense | 1:2 |
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