| 4. Ronde | 09.10.2021 | Mazatlán FC [] | - | Santos Laguna [] | 0:2 | ||||
| 5. Ronde | 16.10.2021 | Club León [] | - | Mazatlán FC [] | 4:2 | ||||
| 6. Ronde | 23.10.2021 | Deportivo Guadalajara [] | - | Mazatlán FC [] | 3:0 | ||||
| 7. Ronde | 30.10.2021 | Mazatlán FC [] | - | Atlas Guadalajara [] | 1:2 | ||||
| 9. Ronde | 13.11.2021 | Mazatlán FC [] | - | Club Necaxa [] | 1:3 |
Mexico