| 1. Ronde | 30.05.2021 | Bahia - BA | - | Santos FC | 3:0 | ||||
| 9. Ronde | 04.07.2021 | América - MG | - | Santos FC | 2:0 | ||||
| 10. Ronde | 07.07.2021 | Santos FC | - | Athletico Paranaense | 2:1 |  |
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| 11. Ronde | 10.07.2021 | Palmeiras | - | Santos FC | 3:2 | |
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| 12. Ronde | 19.07.2021 | Red Bull Bragantino | - | Santos FC | 2:2 | ||||
| 13. Ronde | 25.07.2021 | Santos FC | - | Atlético Goianiense | 0:1 | ||||
| 14. Ronde | 01.08.2021 | Chapecoense | - | Santos FC | 0:1 | ||||
| 15. Ronde | 08.08.2021 | Santos FC | - | Corinthians SP | 0:0 | ||||
| 16. Ronde | 15.08.2021 | Fortaleza - CE | - | Santos FC | 1:1 | ||||
| 31. Ronde | 10.11.2021 | Santos FC | - | Red Bull Bragantino | 2:0 | ||||
| 32. Ronde | 13.11.2021 | Atlético Goianiense | - | Santos FC | 0:0 | |
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| 34. Ronde | 21.11.2021 | Corinthians SP | - | Santos FC | 2:0 | ||||
| 35. Ronde | 25.11.2021 | Santos FC | - | Fortaleza - CE | 2:0 | ||||
| 36. Ronde | 28.11.2021 | Internacional | - | Santos FC | 1:1 | ||||
| 37. Ronde | 07.12.2021 | Flamengo RJ | - | Santos FC | 0:1 | |
Brazilië