| 5. Ronde | 21.08.2021 | Santos Laguna [U16] | - | Atlético San Luis [U16] | 2:0 | ||||
| 8. Ronde | 11.09.2021 | Santos Laguna [U16] | - | Mazatlán FC [U16] | 4:2 | ||||
| 15. Ronde | 30.10.2021 | Santos Laguna [U16] | - | Club Necaxa [U16] | 2:1 | ||||
| 16. Ronde | 06.11.2021 | UANL Tigres [U16] | - | Santos Laguna [U16] | 4:0 | ||||
| 17. Ronde | 13.11.2021 | Santos Laguna [U16] | - | Deportivo Guadalajara [U16] | 0:1 |
Mexico