| 1. Ronde | 05.09.2021 | UD Melilla | - | CD Toledo | 1:0 | ||||
| 2. Ronde | 12.09.2021 | CD Marchamalo | - | UD Melilla | 0:0 |  |
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| 3. Ronde | 18.09.2021 | UD Melilla | - | Recreativo Granada | 1:3 | |
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| 5. Ronde | 03.10.2021 | UD Melilla | - | Mar Menor CF | 2:3 | ||||
| 6. Ronde | 10.10.2021 | UD Alzira | - | UD Melilla | 0:1 | ||||
| 11. Ronde | 14.11.2021 | UD Melilla | - | CF La Nucía | 1:0 | ||||
| 12. Ronde | 21.11.2021 | CD Eldense | - | UD Melilla | 2:1 | ||||
| 13. Ronde | 28.11.2021 | UD Melilla | - | Hércules CF | 1:2 | |
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| 14. Ronde | 05.12.2021 | Real Murcia | - | UD Melilla | 0:0 | ||||
| 15. Ronde | 12.12.2021 | CS Puertollano CF | - | UD Melilla | 1:0 | |
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| 16. Ronde | 19.12.2021 | UD Melilla | - | Águilas FC | 1:1 |
Spanje