| 1. Ronde | 07.08.2021 | SC Cham | - | FC Sion II | 2:1 | ||||
| 3. Ronde | 21.08.2021 | SC Cham | - | FC Zürich II | 3:0 | ||||
| 4. Ronde | 28.08.2021 | FC Breitenrain Bern | - | SC Cham | 1:1 | ||||
| 9. Ronde | 02.10.2021 | FC Bavois | - | SC Cham | 1:4 | ||||
| 10. Ronde | 09.10.2021 | SC Cham | - | FC Stade Nyonnais | 1:3 | ||||
| 11. Ronde | 16.10.2021 | AC Bellinzona | - | SC Cham | 2:1 | ||||
| 12. Ronde | 23.10.2021 | SC Cham | - | BSC Young Boys II | 1:3 | ||||
| 13. Ronde | 31.10.2021 | FC Chiasso | - | SC Cham | 3:0 | ||||
| 14. Ronde | 06.11.2021 | SC Cham | - | FC Biel/Bienne | 2:2 | ||||
| 15. Ronde | 13.11.2021 | FC Basel 1893 II | - | SC Cham | 3:4 | ||||
| 16. Ronde | 20.11.2021 | FC Sion II | - | SC Cham | 3:4 | ||||
| 17. Ronde | 27.11.2021 | SC Cham | - | Etoile Carouge FC | 1:0 | ||||
| 18. Ronde | 04.12.2021 | FC Zürich II | - | SC Cham | 3:1 | ||||
| 22. Ronde | 12.03.2022 | FC Rapperswil-Jona | - | SC Cham | 1:1 | ||||
| 23. Ronde | 19.03.2022 | FC Black Stars Basel | - | SC Cham | 0:2 | ||||
| 24. Ronde | 26.03.2022 | SC Cham | - | FC Bavois | 1:1 |  |
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| 25. Ronde | 02.04.2022 | FC Stade Nyonnais | - | SC Cham | 3:3 |
Zwitserland