| 5. Ronde | 05.02.2022 | Mazatlán FC [] | - | UANL Tigres [] | 1:2 | ||||
| 7. Ronde | 19.02.2022 | Atlas Guadalajara [] | - | UANL Tigres [] | 5:2 | ||||
| 8. Ronde | 26.02.2022 | UANL Tigres [] | - | Deportivo Guadalajara [] | 1:3 | ||||
| 11. Ronde | 19.03.2022 | UANL Tigres [] | - | Mazatlán FC [] | 5:0 | ||||
| 12. Ronde | 26.03.2022 | Club Tijuana [] | - | UANL Tigres [] | 3:1 | ||||
| 13. Ronde | 02.04.2022 | UANL Tigres [] | - | Atlético San Luis [] | 2:0 | ||||
| 14. Ronde | 27.04.2022 | CF Monterrey [] | - | UANL Tigres [] | 2:4 | ||||
| 17. Ronde | 30.04.2022 | UANL Tigres [] | - | Atlas Guadalajara [] | 1:1 | ||||
| 18. Ronde | 07.05.2022 | Deportivo Guadalajara [] | - | UANL Tigres [] | 2:1 |
Mexico