| 1. Ronde | 09.01.2022 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 3. Ronde | 21.01.2022 | Mazatlán FC [U20] | - | Deportivo Toluca [U20] | 1:0 | ||||
| 2. Ronde | 16.02.2022 | Mazatlán FC [U20] | - | CF América [U20] | 2:1 | ||||
| 6. Ronde | 20.02.2022 | Gallos Blancos [U20] | - | Mazatlán FC [U20] | 0:0 |  |
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| 7. Ronde | 24.02.2022 | CF Pachuca [U20] | - | Mazatlán FC [U20] | 3:2 | ||||
| 8. Ronde | 01.03.2022 | Mazatlán FC [U20] | - | Club Necaxa [U20] | 1:3 | ||||
| 10. Ronde | 11.03.2022 | CF Monterrey [U20] | - | Mazatlán FC [U20] | 2:3 | ||||
| 11. Ronde | 20.03.2022 | Mazatlán FC [U20] | - | Club León [U20] | 1:0 | ||||
| 9. Ronde | 27.03.2022 | Pumas UNAM [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 12. Ronde | 01.04.2022 | Atlético San Luis [U20] | - | Mazatlán FC [U20] | 1:2 | ||||
| 14. Ronde | 14.04.2022 | Atlas Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 15. Ronde | 19.04.2022 | Mazatlán FC [U20] | - | Santos Laguna [U20] | 1:2 |  |
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| 16. Ronde | 22.04.2022 | FC Juárez [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 17. Ronde | 29.04.2022 | Mazatlán FC [U20] | - | Puebla FC [U20] | 4:1 |
Mexico