| 1. Ronde | 17.02.2022 | Deportes Melipilla | - | Universidad de Concepción | 0:2 |  |
|||
| 2. Ronde | 24.02.2022 | Rangers | - | Deportes Melipilla | 1:0 | ||||
| 3. Ronde | 02.03.2022 | Deportes Melipilla | - | Puerto Montt | 1:1 | ||||
| 4. Ronde | 12.03.2022 | Recoleta | - | Deportes Melipilla | 1:2 | ||||
| 8. Ronde | 09.04.2022 | Deportes Melipilla | - | Cobreloa | 0:0 | ||||
| 9. Ronde | 18.04.2022 | San Luis | - | Deportes Melipilla | 2:1 | ||||
| 10. Ronde | 21.04.2022 | Deportes Melipilla | - | Santiago Wanderers | 2:0 |  |
|||
| 12. Ronde | 30.04.2022 | Deportes Melipilla | - | Barnechea | 2:1 | ||||
| 16. Ronde | 22.05.2022 | Deportes Melipilla | - | Santa Cruz | 1:0 |  |
|||
| 17. Ronde | 29.05.2022 | Deportes Iquique | - | Deportes Melipilla | 3:0 | ||||
| 19. Ronde | 12.07.2022 | Deportes Melipilla | - | Rangers | 1:2 | ||||
| 21. Ronde | 26.07.2022 | Deportes Melipilla | - | Recoleta | 1:2 | ||||
| 26. Ronde | 31.08.2022 | Deportes Melipilla | - | San Luis | 1:2 | ||||
| 34. Ronde | 01.11.2022 | Deportes Melipilla | - | Deportes Iquique | 0:0 |
Chili