| 1. Ronde | 08.08.2022 | Nottingham Forest U21 | - | Southampton FC U21 | 1:3 | ||||
| 2. Ronde | 12.08.2022 | Southampton FC U21 | - | West Bromwich Albion U21 | 4:1 | ||||
| 3. Ronde | 19.08.2022 | Stoke City U21 | - | Southampton FC U21 | 0:3 |  |
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| 4. Ronde | 26.08.2022 | Southampton FC U21 | - | Norwich City U21 | 1:1 | ||||
| 6. Ronde | 16.09.2022 | Leeds United U21 | - | Southampton FC U21 | 6:2 | ||||
| 8. Ronde | 08.10.2022 | Southampton FC U21 | - | Aston Villa U21 | 2:0 | |
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| 9. Ronde | 23.10.2022 | Newcastle United U21 | - | Southampton FC U21 | 3:2 | ||||
| 11. Ronde | 07.11.2022 | Sunderland AFC U21 | - | Southampton FC U21 | 1:3 | ||||
| 12. Ronde | 06.01.2023 | Southampton FC U21 | - | Derby County U21 | 3:0 | ||||
| 13. Ronde | 13.01.2023 | Southampton FC U21 | - | Newcastle United U21 | 4:1 |  |
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| 14. Ronde | 27.01.2023 | Middlesbrough FC U21 | - | Southampton FC U21 | 2:2 |
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