| 3. Ronde | 27.08.2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 4. Ronde | 11.09.2021 | Tottenham Hotspur U23 | - | Liverpool FC U23 | 2:1 | ||||
| 7. Ronde | 01.10.2021 | Crystal Palace U23 | - | Tottenham Hotspur U23 | 4:3 | ||||
| 9. Ronde | 23.10.2021 | Manchester City U23 | - | Tottenham Hotspur U23 | 1:3 | ||||
| 22. Ronde | 12.03.2022 | Liverpool FC U23 | - | Tottenham Hotspur U23 | 7:1 | ||||
| 23. Ronde | 18.03.2022 | Tottenham Hotspur U23 | - | Leicester City U23 | 3:1 | ||||
| 24. Ronde | 04.04.2022 | West Ham United U23 | - | Tottenham Hotspur U23 | 3:1 | ||||
| 26. Ronde | 02.05.2022 | Tottenham Hotspur U23 | - | Brighton & Hove Albion U23 | 0:0 | ||||
| 20. Ronde | 08.05.2022 | Chelsea FC U23 | - | Tottenham Hotspur U23 | 2:1 |
Estland